Hearing loss

The mechanism of hearing loss arises from trauma to stereocilia of the cochlea, the principal fluid filled structure of the inner ear.^{[citation needed]} The pinna combined with the middle ear amplifies sound pressure levels by a factor of twenty, so that extremely high sound pressure levels arrive in the cochlea, even from moderate atmospheric sound stimuli. Underlying pathology to the cochlea are reactive oxygen species, which play a significant role in noise-induced necrosis and apoptosis of the stereocilia. Exposure to high levels of noise have differing effects within a given population, and the involvement of reactive oxygen species suggests possible avenues to treat or prevent damage to hearing and related cellular structures.

The elevated sound levels cause trauma to the cochlear structure in the inner ear, which gives rise to irreversible hearing loss. A very loud sound in a particular frequency range can damage the cochlea's hair cells that respond to that range thereby reducing the ear's ability to hear those frequencies in the future. However, loud noise in any frequency range has deleterious effects across the entire range of human hearing. The outer ear (visible portion of the human ear) combined with the middle ear amplifies sound levels by a factor of 20 when sound reaches the inner ear.

Hearing loss is somewhat inevitable with age. Though older males exposed to significant occupational noise demonstrate significantly reduced hearing sensitivity than their non-exposed peers, differences in hearing sensitivity decrease with time and the two groups are indistinguishable by age 79. Women exposed to occupational noise do not differ from their peers in hearing sensitivity, though they do hear better than their non-exposed male counterparts. Due to loud music and a generally noisy environment, young people in the United States have a rate of impaired hearing 2.5 times greater than their parents and grandparents, with an estimated 50 million individuals with impaired hearing estimated in 2050.

In Rosen's work on health effects and hearing loss, one of his findings derived from tracking Maaban tribesmen, who were insignificantly exposed to transportation or industrial noise. This population was systematically compared by cohort group to a typical U.S. population. The findings proved that aging is an almost insignificant cause of hearing loss, which instead is associated with chronic exposure to moderately high levels of environmental noise.